The Palladium shut on Friday (December 17) due to the incident – which occurred in area where work is taking place on the ceiling.
The pub, based at the former Palladium theatre and cinema, is expected to reopen today (Saturday).
A Wetherspoons spokesperson said: “There is scaffolding in the pub as work is being undertaken on the ceiling.
“There is a safety net, so there is no danger to customers.
“A piece of the ceiling fell into the net early on Friday morning. No customers were in the pub.
“Wetherspoon has decided to reopen the pub once more scaffolding is in place.
“It is hoped the pub will reopen today (Saturday).”